US Central Command (CENTCOM) said in a statement that five others have been 'seriously wounded'.
Explosions heard in Tel Aviv as Israeli rescue services report casualties in Beit Shemesh missile attack.
Iran's defence minister and the commander-in-chief of the IRGC are among those killed in the US and Israel's attack.
Preliminary figures are 201 dead in Iran, at least nine in Israel, and three US soldiers killed.
The Magen David Adom (MDA) emergency service says that 20 others were injured by the impact.
Several nations, global bodies and prominent groups respond to killing of Iran's supreme leader, urging de-escalation.
Ayatollah Ali Khamenei's assassination brings Iran's clerics the colossal task of picking his successor.
About 20-30 percent of global oil and gas supplies are shipped through the Strait of Hormuz.
The crossing with Egypt is considered vital for delivery of humanitarian aid and evacuation of critically ill patients.
Security chief Larijani pledges swift establishment of provisional council as Iran navigates its leadership transition.